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Melatonin is the chemical expression of darkness.
Melatonin is secreted from the pineal gland, the seat of the soul, the third eye. Pinealectomy induces circadian arrhythmia and has interesting effects on adipose tissue biology. Exhibit A. In 2004,...
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Paleo Plants and Carnivory
From what I gather, it’s been difficult to pinpoint the role of plants in the diet of our ancestors for a variety of reasons. For example, evidence of plants on cooking tools and dental remains is...
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Ketosis is a hack: here’s why
There are multiple distinct flavors of diabetes/obesity, as evidenced by the fact that some people have: 1) impaired glucose tolerance (but normal fasting glucose); 2) others have impaired fasting...
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A brief explanation of Hall et al., ie, THE LOW CARB WAR
“Examination of acute shifts in energy balance by selectively reducing calorie intake from one macronutrient.” Intro (1/2): please don’t read this study with the media headlines in your mind. Don’t...
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“Insulin Dynamics”
This one has a bit for everyone. Relationship of Insulin Dynamics to Body Composition and Resting Energy Expenditure Following Weight Loss (Hron et al., 2015) I think study was actually done a few...
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The “Insulin Index”
Similar to the glycemic index, which is an estimate of the rise in blood glucose after eating a particular food, the insulin index is an estimate of the rise in insulin after eating a particular food....
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Personalized Nutrition by Prediction of Glycemic Responses
“please stop asking gurus how many carbs you need to optimize health” An interesting paper came out recently by Zeevi et al. (2015), showing, in part, that we’re all unique snowflakes (in some...
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Personalized Nutrition II
More on Zeevi et al. (2015) (this is a follow-up to part 1) I like this study a lot, or at least the fundamentals… or new tools that it might bring to the table. Like, we know sleep and physical...
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Tissue-specific fatty acid oxidation
Does it matter where fatty acids are oxidized, liver or skeletal muscle? Of course, they’re oxidized in both tissues (quantitatively much more in the latter), but relative increases in one or the...
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Ketone supps
1st Generation: ketone salts. Only problem is the huge dose of salt limits how much you can take without adverse effects… but these are the ones on the market. 2nd Generation: ketone esters....
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AMYLIN
Brief background reading: amylin (according to Wikipedia) In a study by Hollander on type II diabetics, the synthetic amylin analog pramlintide was tested (Hollander et al., 2003). In this year-long...
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Melatonin sensitizes the system
Bear with me here… this could be very important (or just all in my imagination haha) Fact: melatonin secretion happens at night (or at least that’s when it’s supposed to happen): And it’s important...
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Social jet lag
Social jet lag is basically a general term that refers to circadian arrhythmia. Sort of like insulin resistance, it’s rampantly abundant — some have estimated a prevalence of up to 75%! Social jet...
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the insulin-obesity hypothesis is under attack
…but it isn’t dead, imo, because that would be really hard to do. Like, seriously. Wait, which “insulin hypothesis” was falsified? pic.twitter.com/31pOP9B6Ff — Bill Lagakos (@CaloriesProper) May 11,...
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Vasopressin’ me again
I’ve been following the links between blood pressure modulatory hormones and circadian rhythms for a while now — and while it’s a fascinating overall picture, this nut hasn’t been cracked [yet]. A...
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Dopamine and breakfast
While opining on her latest protein-rich breakfast experiment, Jane Plain mentioned ghrelin as an important mediator of the circadian component (more on this below). T.S. Wiley wrote a lot about the...
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Insulin resistance and obesity
Some people believe insulin resistance (IR) causes obesity, and they are not pleased when I say this is actually a controversial topic in the field… “Bill isn’t toeing the company line. Again.” So I...
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LIGHT timing for circadian entrainment
Basically, this much is pretty obvious now: LIGHT and food in the morning + darkness after sunset = proper circadian entrainment. But the how is pretty cool; LIGHT affects different biochemical...
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Gypped by GIP
Dr. Johnson’s recent paper is nothing short of a monster. They did a TON of experiments. Here, I only want to focus on one aspect. The insulin-obesity hypothesis in a nutshell (very oversimplified):...
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Circadian rhythms and prostate cancer
Observations: Incidence of prostate cancer is higher among pilots, flight attendants, and rotating shift workers than the general population (RR as high as 3.0 in some cases!). Circadian rhythms of...
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